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Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension.

Stiefel P, Argüelles S, García S, Jiménez L, Aparicio R, Carneado J, Machado A, Ayala A

Unidad de Hipertension y Lipidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Seville, Spain.

Oxidative stress seems to play an important role in the pathophysiology of essential hypertension. Due to its antioxidant features, we studied the protective action of folic acid in hypertensive patients, their food supplemented for 2 weeks with this vitamin. Several oxidative stress parameters were measured in the serum of these patients. The results show that folic acid supplementation improves levels of oxidative stress markers in individuals with hypertension, overall in those patients whose initial parameter values were highest.

Published 15 November 2005 in Biochim Biophys Acta, 1726(2): 152-9.
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