Hypertension Research Today is a free monthly online journal that collates and summarizes the latest research about Hypertension, including details on symptoms, diagnosis, diet, treatment, causes. | ||||||||
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The conduction of dilation along an arteriole is diminished in the cremaster muscle of hypertensive hamsters.Kurjiaka DT Department of Biological Sciences, Ohio University, 302 Wilson Research, Athens, OH 45701, USA. kurjiaka@ohiou.edu Arteriolar vasomotor responses can include a component that conducts along the vessel through gap junction channels. This study examined conducted vasomotor responses in arterioles of the hypertensive hamster. The cremaster muscle of normotensive (CHF-148) and spontaneously hypertensive (CHF-H4) hamsters was exteriorized. Micropipettes containing phenylephrine (0.1 M) or acetylcholine (ACh; 1.0 M) were positioned along second-order arterioles and diameter responses were recorded locally for every 0.4 mm upstream to 1.6 mm. Substantative local constrictions to phenylephrine(PE) were poorly conducted to the 0.4-mm site in normotensive and hypertensive hamsters. Local dilation to ACh decayed by 3 +/- 1 microm/mm as it conducted along arterioles of the normotensive hamster. In contrast, conducted dilation decayed by 7 +/- 1 microm/mm (p < 0.05) in the hypertensive hamster. This hypertension-induced increase in decay was reversed by alpha-adrenergic receptor blockade (phentolamine: 1 microM). However, arteriolar constriction to global alpha(1)- (PE) and alpha(2)- (clonidine) adrenergic agonists was unaffected by hypertension. Rather, sympathetic nervous activity was elevated in the hypertensive hamster as indicated by a greater reduction in arterial pressure upon sympathetic ablation (hexamethonium infusion: 30 mg/kg). This study provides the first evidence that vascular cell-cell communication is altered by the elevated sympathetic nervous activity observed in the hypertensive hamster. Published 7 December 2004 in J Vasc Res, 41(6): 517-24.
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