Hypertension Research Today is a free monthly online journal that collates and summarizes the latest research about Hypertension, including details on symptoms, diagnosis, diet, treatment, causes.

Association between -786TC polymorphism in the endothelial nitric oxide synthase gene and hypertension in the Tunisian population.

Jemaa R, Kallel A, Sediri Y, Omar S, Feki M, Elasmi M, Haj-Taieb S, Sanhaji H, Kaabachi N

Research Laboratory LR99ES11, Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia. jemaa_riadh@yahoo.fr

Published 4 March 2011 in Exp Mol Pathol, 90(2): 210-4.
Full-text of this article is available online (may require subscription).

Articles on Hypertension published 3 March 2011:

Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy.   Clin Sci (Lond), 120(8): 335-45.

ACE (angiotensin-converting enzyme) 2 is expressed in the heart and kidney and metabolizes Ang (angiotensin) II to Ang-(1-7) a peptide that acts via the Ang-(1-7) or mas receptor. The aim of the present study was to assess the effect of Ang-(1-7) on blood pressure and cardiac remodelling in a rat model of renal mass ablation. Male SD (Sprague-Dawley) rats underwent STNx (subtotal nephrectomy) and were treated for 10 days with vehicle, the ACE inhibitor ramipril (oral 1 mg·kg(-1) of body ... [Abstract] [Full-text]

Articles on Hypertension published 28 February 2011:

The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial.   Lancet, 377(9767): 741-50.

[Abstract] [Full-text]

Articles on Hypertension published 22 February 2011:

Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies.   Heart, 97(6): 479-84.

[Abstract] [Full-text]

Articles on Hypertension published 17 February 2011:

Primary aldosteronism among newly diagnosed and untreated hypertensive patients in a Swedish primary care area.   Scand J Prim Health Care, 29(1): 57-62.

[Abstract] [Full-text]

Articles on Hypertension published 14 February 2011:

The impact of the AIDS Drug Assistance Program (ADAP) on use of highly active antiretroviral and antihypertensive therapy among HIV-infected women.   J Acquir Immune Defic Syndr, 56(3): 253-62.

[Abstract] [Full-text]

Articles on Hypertension published 11 February 2011:

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.   Science, 331(6018): 768-72.

Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two recurrent somatic mutations in and near the selectivity filter of the potassium (K(+)) channel KCNJ5 that are present in 8 of 22 human APAs studied. Both produce increased sodium (Na(+)) conductance and cell depolarization, which in adrenal glomerulosa ... [Abstract] [Full-text]

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.   Science, 331(6018): 768-72.

Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of severe hypertension, feature constitutive hormone production and unrestrained cell proliferation; the mechanisms linking these events are unknown. We identify two recurrent somatic mutations in and near the selectivity filter of the potassium (K(+)) channel KCNJ5 that are present in 8 of 22 human APAs studied. Both produce increased sodium (Na(+)) conductance and cell depolarization, which in adrenal glomerulosa ... [Abstract] [Full-text]

Association of polymorphisms in the solute carrier organic anion transporter family member 1B1 gene with essential hypertension in the Uyghur population.   Ann Hum Genet, 75(2): 305-11.

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) is an important hepatic uptake transporter that can transport a wide variety of endogenous compounds, including thyroid hormones and prostaglandin E2. Dysregulation of thyroid hormones and prostaglandin E2 plays a role in the development of hypertension, suggesting that SLCO1B1 might contribute to the aetiology of essential hypertension (EH). In this study, we selected five single nucleotide polymorphisms (SNPs) at the SLCO1B1 ... [Abstract] [Full-text]

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